Griffiths starts up front as Strachan rings changes for England clash
Craig Gordon and Ikechi Anya have also come into the Scotland team for the qualifier.
Leigh Griffiths will start up front for Scotland with Gordon Strachan ringing the changes for the World Cup qualifier against England.
Craig Gordon has come in for David Marshall in goals, with Ikechi Anya also starting at right back over Callum Paterson for the Dark Blues at Wembley.
There are eight changes in all to Scotland's starting lineup from last month's World Cup qualification defeat to Slovakia, with Lee Wallace playing at left back following injuries to Andy Robertson and Kieran Tierney.
Christophe Berra has also come in to partner Grant Hanley as the centre back pairing, with Russell Martin dropping out.
Scott Brown has been restored to the midfield after his decision to come out of international retirement, with the 31-year-old playing alongside Darren Fletcher and James Morrison in a central trio.
James Forrest has also been brought into the lineup, replacing Matt Ritchie from the side that lost in Trnava.